How does a cell regulate the access to the information encoded in its DNA? Their misregulation can severely impair cell differentiation and is associated with the development of leukemia and other forms of cancer. The human genome is organized by wrapping the DNA around small histone proteins. Gene activation requires freely accessible DNA, and genes can be inactivated by occluding DNA parts within a nucleosome complex. Hence, the nucleosome positions determine a read out pattern: Information in the DNA linker region between nucleosomes is more easily accessible as opposed to sequences that are blocked by histone-DNA interactions. They are an essential part of a regulatory network that allows the cell to select specific programs to differentiate into a muscle cell, a nerve cell or a skin cell from the identical genetic information. A given remodeler binds to a nucleosome typically for only a tenth or a hundredth of a second and then detaches to test another nucleosome until it finds one that carries some special feature to bind it more tightly. Only if the two of them fit together well, the remodeler gets hooked up to the nucleosome: It stays for seconds or even minutes to shift it to a new position on the DNA, then dissociates and moves on. But if you need them they show up in no time. Thus, the next challenge in understanding their function will be to decipher the signals that make them stick to one nucleosome and not the others.
Questions and Answers
Data management is generally recognized as a crucially important but challenging part of Systems Biology. Data management systems that are useful, usable and used are difficult to get right. It is not easy to find out about already existing software, or the state of standards that could or should be adopted. Following the outstanding success of the Systems Biology Software Developers Workshop in , we propose the next meeting in the series that enables practitioners in the field to meet like-minded scientists, show their working and upcoming developments, and give opportunities to team up.
A meeting to socialize, yes. But also a meeting to figure out how we can improve collaboration of data management practitioners beyond project borders in the light of ESFRI and other, national infrastructure movements, as well as the move from systems biology to systems medicine and synthetic biology.
Publisher: Springer Berlin Heidelberg. Published in: Intelligent Virtual Agents.» Get access to the full-text. In earlier studies, user involvement with an embodied.
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In earlier studies, user involvement with an embodied software agent and willingness to use that agent were partially determined by the aesthetics of the design and the moral fiber of the character. We used these empirical results to model agents that in their turn would build up affect for their users much the same way as humans do for agents. Through simulations, we tested these models for internal consistency and were successful in establishing the relationships among the factors as suggested by the earlier user studies.
This paper reports on the first confrontation of our agent system with real users to check whether users recognize that our agents function in similar ways as humans do.
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The German passenger airship LZ Hindenburg caught fire and was destroyed during its attempt to dock with its mooring mast at Naval Air Station Lakehurst. There were 35 fatalities 13 passengers and 22 crewmen from the 97 people on board 36 passengers and 61 crewmen , and an additional fatality on the ground. The disaster was the subject of newsreel coverage, photographs, and Herbert Morrison ‘s recorded radio eyewitness reports from the landing field, which were broadcast the next day.
The event shattered public confidence in the giant, passenger-carrying rigid airship and marked the abrupt end of the airship era. After opening its season by completing a single round-trip passage to Rio de Janeiro , Brazil, in late March, the Hindenburg departed from Frankfurt , Germany, on the evening of May 3, on the first of 10 round trips between Europe and the United States that were scheduled for its second year of commercial service.
American Airlines had contracted with the operators of the Hindenburg to shuttle the passengers from Lakehurst to Newark for connections to airplane flights. Except for strong headwinds that slowed its progress, the Atlantic crossing of the Hindenburg was otherwise unremarkable until the airship attempted an early-evening landing at Lakehurst three days later on May 6. Although carrying only half its full capacity of passengers 36 of 70 and crewmen 61, including 21 crewman trainees for the accident flight, the Hindenburg was fully booked for its return flight.
Many of the passengers with tickets to Germany were planning to attend the coronation of King George VI and Queen Elizabeth in London the following week. The airship was hours behind schedule when it passed over Boston on the morning of May 6, and its landing at Lakehurst was expected to be further delayed because of afternoon thunderstorms. Advised of the poor weather conditions at Lakehurst, Captain Max Pruss charted a course over Manhattan Island , causing a public spectacle as people rushed out into the street to catch sight of the airship.
However, as this would leave much less time than anticipated to service and prepare the airship for its scheduled departure back to Europe, the public was informed that they would not be permitted at the mooring location or be able to visit aboard the Hindenburg during its stay in port. This was to be a high landing, known as a flying moor , because the airship would drop its landing ropes and mooring cable at a high altitude, and then be winched down to the mooring mast.